First RegenBell symposium on Stem Cells and Regenerative Medicine

Institut d’Estudis Catalans (IEC), C/ del Carme, 47 08001 Barcelona

MONDAY, NOVEMBER 27

9:00

Registration

9:30

Welcome
Angel Raya, ICREA/IDIBELL & P-CMR[C], L’Hospitalet de Llobregat

9:40

SESSION I: Mechanisms of developmental hematopoiesis
Chair: Alessandra Giorgetti, IDIBELL, P-CMR[C] and UB, L’Hospitalet de Llobregat

9:45

The role of GATA2 in normal and malignant hematopoiesis-What can we learn from Zebrafish?
Emma de Patter, Erasmus Medical Center, Rotterdam

10:15

Specification of Hematopoietic Stem cells: from embryo development to embryonic stem cells.
Anna Bigas, IMIM/IJC, Barcelona

10:45

Selected short talks:

CRISPR/Cas9 Gene Editing in Hematopoietic Stem Cells to Model Clonal Competition in vivo and in vitro for GATA2 Deficiency
Damià Romero, IDIBELL, L’Hospitalet de Llobregat

Heritable states influence stem cell fates upon acquisition of cancer mutations
Indranil Singh, IRB, Barcelona

Generation of a bank of clinical-grade, HLA homozygous iPSC lines with high coverage of the Spanish population
Bernd Kuebler, IDIBELL, L’Hospitalet de Llobregat

11:15

Coffee break

11:45

SESSION II: Aging, metabolism and stem cells
Chair: Mireya Plass, IDIBELL & P-CMR[C], L’Hospitalet de Llobregat

11:50

Aging hematopoietic stem cells: epigenetic drift and remodelling of the niche
M. Carolina Florian, ICREA/IDIBELL & P-CMR[C], L’Hospitalet de Llobregat

12:20

RNA sensors during developmental transitions
Eirini Trompouki, IRCAN, Nice

12:50

Selected short talks:

Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair
Marta Kovatcheva, IRB, Barcelona

The Interferon γ Pathway Enhances Pluripotency and X-Chromosome Reactivation in iPSC Reprogramming
Mercedes Barrero, CRG, Barcelona

Endothelial-Jag2 preserves HSC function upon aging by maintaining HSC epigenetic polarity through Notch signaling activation
Francesca Matteini, IDIBELL, L’Hospitalet de Llobregat

13:20

Flash talks

13:30

LUNCH & posters

15:15

SESSION III: Making sense of complexity
Chair: Angel Raya, ICREA/IDIBELL & P-CMR[C], L’Hospitalet de Llobregat

15:20

Multiscale Computational modelling in stem cell research and regenerative medicine
Antonio del Sol, LCSB, Luxembourg

15:50

Selected short talks:

Self-protection by epithelial cells in the early embryo
Joan Roncero, IDIBELL, L’Hospitalet de Llobregat

Epigenetic modifications driving ground state pluripotency exit require an NF-κB-independent chromatin IκBα function
Luis Galán Palma, IMIM/IJC, Barcelona

A dynamic gradient of extracellular matrix stiffness orchestrates zebrafish heart regeneration
Ioannis Lazis, IDIBELL, L’Hospitalet de Llobregat

16:20

Coffee break

17:00

Gastruloids: non-integrated stem cell models of mammalian gastrulation and body plan engineering
Alfonso Martinez Arias, ICREA/UPF, Barcelona

17:30

ROUND TABLE: Translation of regenerative Medicine & GMP
Moderator Anna Veiga, IDIBELL & P-CMR[C], L’Hospitalet de Llobregat

Participants:
Sergi Querol, BST, Barcelona The scientists’ view
Jordi Monés, BMF, Barcelona. The clinicians’ view
Sara Varea, Hospital Clínic, Barcelona. The regulators’ view

18:30

Flash talks

18:45

Poster session

20:00

End of the session

TUESDAY, NOVEMBER 28

9:00

SESSION IV: Modeling development and disease
Chair: Esteban Hoijman, IDIBELL and UB, L’Hospitalet de Llobregat

9:05

Modeling herpes simplex virus 1 infection in cerebral organoids reveals new potential therapeutic approaches for viral encephalitis
Agnieszka Rybak-Wolf, MDC Berlin, Berlin

9:35

Modelling human development using embryo culture and pluripotent stem cell models
Fredrik Lanner, KI, Solna

10:05

Selected short talks:

Midbrain organoids with LRRK2 G2019S mutation recapitulate key aspects of PD pathology and reveal early glia dysfunction
Veronica Testa, UB, L’Hospitalet de Llobregat

A 3D atlas of the human embryonic and fetal pancreas to study proliferation and differentiation of multipotent pancreatic progenitors
Adrian Villalba, Institut Cochin, Paris

Post-transcriptional regulation in iPSC derived neural and glial cells from Alzheimer disease patients
Marcel Schilling, IDIBELL, L’Hospitalet de Llobregat

10:35

Coffee break

11:05

SESSION V: Organ and tissue regeneration
Chair: Meritxell Rovira, IDIBELL, P-CMR[C] and UB, L’Hospitalet de Llobregat

11:10

Guiding Intestinal Epithelial Stem Cell Fate
Kim B. Jensen, reNEW, Copenhagen

11:40

Selected short talks:

Macrophages crosstalk with intestinal epithelial cells to regulate regeneration
Ilias Moraitis, IDIBELL, L’Hospitalet de Llobregat

Decoding pancreatic endocrine cell differentiation and beta-cell regeneration in zebrafish
Olov Andersson, KI, Solna

Characterization of the murine pancreatic ductal tree identifies novel cell populations with potential implications in pancreas regeneration
Ángel Fernández, UPF, Barcelona

12:10

Beta cell development and regeneration
Heiko Lickert, Helmholtz Munich, Munich

12:40

Poster/short talk award and concluding remarks
Jordi Guiu, IDIBELL & P-CMR[C], L’Hospitalet de Llobregat

13:00

End of the conference

Event sponsored by: